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U.S. Environmental Protection Agency (EPA) provide evaluations and is despostory of cataloged analysis. They also rank problems like, like indoor air pollution. commonly called sick building syndrome. They state that it is costing businesses $60 billion annually. I’ll will get into the data later but I want to discuss, how do we protect human health and quality of life? By reducing chemical exposure and improve indoor air quality?
What I’m finding out it’s not just the enviroment, it’s a human’s immune system. I’m not trying to be clever but create a debate that simply states that IAQ is a moving target. Molds that are everywhere, I have to refere to an expert, Serum IgE “Specific to Indoor Molds, Measured by Basophil Histamine Release, is Associated with Building-related Symptoms in Damp Buildings” FROM: Inflamm Res 2001; 50 (4) Apr: 227–31 Lander F, Meyer HW, Norn S National Work Environment Authority, Copenhagen, Denmark. fla@arbejdstilsynet. dk OBJECTIVE: To study the relationship between basophil histamine release (HRT) to indoor moulds, indicating specific IgE, and building-related symptoms (BRS), asthma, and hay fever in individuals working in damp and mouldy buildings. METHODS: A cross-sectional study was performed among 86 school staff members, who on average had worked 143 months (range: 3-396) in moist buildings with mould growth in the constructions.
A questionnaire concerning mucous membrane symptoms, facial skin symptoms, central nervous system symptoms, hay fever, and asthma was fulfilled by the participants, and blood samples were taken. Eight mould species growing on building constructions were identified and cultivated to obtain allergenic materials for testing. The presence in serum of IgE specific to moulds was verified by histamine release test (HRT) based on passive sensitization of basophil leukocytes. The validity of the method was confirmed by parallel testing of patients allergic to grass- and birch pollen and by the shift from positive to negative response after removal of serum IgE and by using sham sensitization. RESULTS: The prevalence of most BRS was between 32% and 62%. Positive HRT, showing serum IgE specific to one or more of the moulds, was observed in 37% of the individuals.
The highest frequency of positive HRT was found to Penicillium chrysogenum and then to Aspergillus species, Cladosporium sphaerospermum and Stachybotrys chartarum. A significant association was found between most BRS and positive HRT, whereas no association was observed between positive HRT to moulds and self reported hay fever or asthma. CONCLUSION: Positive HRT to indoor moulds, showing the presence in serum of IgE specific to the fungi, was found to be related to BRS in individuals working in damp and mouldy buildings. Whether the association is of causal character is a question for further studies. The test may be useful in the evaluation and study of possible mould induced BRS. The debate is FROM: Environ Health Perspect 1999; 107 Suppl 3 Jun: 485–7, Holt PG Sensitization to inhalant allergens commonly commences in utero, and most children are born with weak T helper–2 (Th2)–polarized T–cell immunity to these agents.
During early life, these responses are normally deviated toward the Th1 cytokine profile. However, in atopics this immune deviation process fails, leading instead to consolidation of allergen–specific Th2 immunity and its eventual active expression in the airways. Both the induction and expression of Th2 immunity can be modulated by environmental agents that affect the cytokine milieu in the airway mucosa and/or the draining lymph nodes. Because of the known effects of the mold cell wall component (1–>3)-ss–d–glucan on monocyte cytokine secretion, exposure to molds during childhood may be a significant etiologic factor in allergic respiratory disease in general. These moulds (molds) exsist every where and they have the ability to change our immmune system. If we are sick the response is slower… consider this, if environmental agents are attacking, systems is less sensitive to phagocytosis, while in a health system macrophage are already present.